ICT Archives - Basel Area Business & Innovation About Basel Area Business & Innovation Thu, 24 Oct 2024 13:58:43 +0000 en-US hourly 1 https://wordpress.org/?v=6.7.1 https://baselarea.swiss//wp-content/uploads/2019/10/cropped-basel-area-favicon-01-32x32.png ICT Archives - Basel Area Business & Innovation 32 32 Opportunities in the Metaverse https://baselarea.swiss/blog-post/opportunities-in-the-metaverse/ Wed, 04 Oct 2023 08:24:00 +0000 https://baselarea.swiss/?post_type=blog_post&p=150771 In our 12th iteration of the Technology Circle (21.06.2023), we learned from four speakers what the metaverse is and what opportunities it creates in various industries. We also officially concluded the Interreg Titan-e program.

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Opportunities in the Metaverse

In our 12th iteration of the Technology Circle (21.06.2023), we learned from four speakers what the metaverse is and what opportunities it creates in various industries. We also officially concluded the Interreg Titan-e program.

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What is the metaverse?

The metaverse changes how we virtually interact, trade, solve problems and collaborate with each other. It’s the next evolution of the internet that transforms our interaction with the digital world like never before.

There isn’t one unified metaverse. It’s the concept of a virtual, shared and interconnected digital space where users can interact with each other and digital objects in real-time.

It takes many forms, some of which you’ll learn more about here.

We can all benefit from the metaverse

The first thought that comes to mind when you think about virtual reality is probably gaming. But the metaverse has opportunities in store beyond entertainment.

The metaverse for consumers

• Media consumption
• Socializing
• Shopping
• Gaming

Consumers love different ways to interact with the brands and entertainment providers they love. Inside the metaverse, they can shop in their favorite stores, enjoy a movie at the cinema or play a few hands of poker with their best buddies – all from the comfort of their homes.

The metaverse for enterprises

• Recruiting & hiring
• Customer support
• Collaboration
• Training

Businesses are eager to fill the above-described customer needs. For example, 33 million people saw Lil Nas X’s 10 minutes show on Roblox, resulting in 8 figures merch sales. Beyond fulfilling customer needs, businesses can use the metaverse to train staff, visualize prototypes and collaborate more humanly across long distances.

The metaverse for the manufacturing industry

• Digital twins
• Planning and performance optimization
• R&D
• Predictive maintenance

Every complex, physical system can be digitally mirrored in the metaverse. This digital twin allows for predicting production problems and testing optimizations before implementing them in the real world.

Focus: The metaverse for the manufacturing industry

With our Technology Circle events, we bring industry 4.0 technology topics to the Basel Area. As the industrial transformation team of the Basel Area, our main focus in this section of the event is on the manufacturing industry.

“The industrial metaverse is not merely a single technology. Rather, it represents an integrated ecosystem.”
—Isabel Steinhoff, Transformation & Metaverse Strategist, Co-Founder at Dimenteers

Isabel shows us the positive impact of metaverse on the manufacturing industry with three examples.

For Nestlé, ensuring that all manufacturing safety procedures are followed correctly is critically important. With its digital twin of the Nescafé factory in Girona, northern Spain, Nestlé teaches safety, hygiene and traffic rules of the large facility in a safe, virtual environment. Employees can go through vital safety training without endangering themselves or the factory without even being on the premises.

Swissgrid faced challenges with outsourcing and risk management. With the help of Rimon, one of our former i4Challenge winners, they digitized their monthly inspection process and enabled untrained people to execute it using augmented reality (AR). They streamlined inspections, improved quality, standardized the process and enhanced know-how management.

BMW built a digital twin of a factory before actually building it and simulated 6 months of production. Thanks to the learnings of this simulation, BMW changed the design before construction. This made the planning process 30% more efficient, saved 10% in production costs and about 80% of meetings could be skipped or streamlined due to high information availability.

There are many more opportunities that save cost, improve safety and efficiency and have an overall positive impact on people, the environment and the company’s bottom line.

The metaverse is here to stay. It will impact all facets of our private and business life. You should start engaging and experimenting today.

Isabel SteinhoffTransformation & Metaverse Strategist, Co-Founder at Dimenteers

Healing in the metaverse

As Europe’s leading life sciences ecosystem, healthcare is most dear to our hearts and was our primary focus in this event. The opportunities for healing in the metaverse are endless.

Philippe Gerwill presented a few apt use cases, followed by a tour of the Avalon health city by Aimedis, where he is Executive Advisor.

Nobody anticipated the transition from paper to smartphones. Now, the future lies in moving from smartphones to the metaverse.

Philippe GerwillDigitalization Humanist

Personal fitness and mental health

Healthcare is most often sick care. We tend to treat people instead of preventing illnesses. But this trend is shifting towards wellness and preventive care, especially with the younger generation.

A way to nudge people towards preventive care is by giving them incentives. Today, these incentives already exist as tokens or NFTs. With the metaverse, we can gamify preventive healthcare even more.

For example, with a fun home workout:

The metaverse also offers interesting opportunities for one’s mental health.

Imagine doing a yoga exercise in an immersive environment that makes you feel like you’re on a beach rather than in your own room. The same goes for meditation.

The idea is not only to transport yourself elsewhere but also to access the expertise of people anywhere in the world. You could experience guided meditation by monks in Tibet, or join a workout session with your favorite fitness star.

Telemedicine

The COVID-19 pandemic forced us to minimize doctor visits to avoid potential exposure to the virus. Telemedicine was heavily worked on before, but COVID accelerated its acceptance across the board.

With the metaverse, people from all over the world could walk into a virtual hospital and receive care from the best health professionals around the globe – neither of them would even have to leave their living rooms.

We should only go to hospitals or doctors when necessary and handle as much as possible from the comfort of our own homes. I believe most people prefer to avoid hospitals whenever they can.

Philippe GerwillDigitalization Humanist

While cameras and a conversation are a start, they often aren’t enough to diagnose health issues accurately. That’s why we need to use new sensor technology like smartwatches, home medical equipment and even smart pills.

Medical training

Someone has to be a doctor’s first patient. Aspiring doctors can practice as many procedures as they want inside the metaverse without risk to an actual patient.

Students can gain hands-on experience or learn in an immersive, reactive environment instead of reading books in a cold classroom.

Medical procedures

In the metaverse, we can access the best technology and expertise from top professionals worldwide. We’re not limited by our physical surroundings. For example, in surgical procedures, we can pilot robots from afar and have as many steady hands as we need:

Few hospitals are equipped with this kind of technology. But even with normal VR goggles, you can effectively use the metaverse for medical procedures. For example, distracting children with games during injections has proven effective.

Closing the Interreg Titan-e project

The Titan-e project ran for the past three years. It aimed to bridge the gap between scientific institutions and entrepreneurs, fostering collaboration, knowledge exchange and technological advancements in the Upper Rhine region, encompassing Switzerland, Alsace, and Baden.

The project focused on advancements in innovation and technology. Academic institutions, entrepreneurs and various organizations came together to advance the region’s economy and contribute to overall well-being.

Looking ahead, I hope we can continue with new projects together. We have done significant work in networking and in communicating the possibilities in the Upper Rhine region.

René OhlmannManaging Director at ADDI-DATA

As part of Titan-E, ADEUS has developed a cross-border network on health technologies in the Upper Rhine. This cartography takes the form of a dynamic visualization of the ecosystem through the representation of its actors and the interactions in which small and medium-sized enterprises are involved.

Our project's uniqueness lies in not only showcasing the ecosystem of the high-tech region but also focusing on the collaborations and innovation projects between organizations.

David MarxDirecteur d’étude at ADEUS

Under Titan-e, we also brought the i4Challenge to live. It provides mentoring, support and visibility to startups and SMEs with promising ideas in various industry 4.0 topics like robotics, AI and sustainability.

In the years 2021 and 2022, a total of 71 projects applied to the competition. A tri-national jury of experts from both industry and academia evaluated these projects to identify the best ones and offer them further development opportunities.

The last iteration of the i4Challenge is now closed. And while the Interreg project Titan-e is over, we’re still committed to providing the latest insights and promote collaboration in the community of the Basel Area and across its borders.

So stay tuned for our next Technology Circle event. We’ll announce its topic soon via email.

The i4Challenge winners showcased innovative solutions in various fields and many of them have achieved great success. Their testimonials speak for the positive impact of the competition.

Albert HilberManager Upper Rhine, Industrial Transformation at Basel Area

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Sébastien MeunierDirector Industrial Transformation

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biGENIUS receives 2 million euros for new cloud product https://baselarea.swiss/blog-post/bigenius-receives-2-million-euros-for-new-cloud-product/ Tue, 03 Oct 2023 14:43:52 +0000 https://baselarea.swiss/?post_type=blog_post&p=151771 Software company biGENIUS, based in the Basel Area, has secured financing of 2 million euros. This funding was granted following the release of biGENIUS-X. The new cloud solution for analytical data automation is able to adapt to changing data landscapes.

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biGENIUS receives 2 million euros for new cloud product

03.10.2023

Software company biGENIUS, based in the Basel Area, has secured financing of 2 million euros. This funding was granted following the release of biGENIUS-X. The new cloud solution for analytical data automation is able to adapt to changing data landscapes.

The team of biGENIUS (image: website biGENIUS)

biGENIUS has secured fresh investment of 2 million euros, as the software firm from Pratteln in the canton of Basel-Landschaft writes in a press release. The financing comes of the back of the release of a new solution for analytical data automation. “As a new product, we can design biGENIUS-X to effectively adapt to the ever-changing data landscape”, comments Thomas Gassmann, Chief Technology Officer of biGENIUS, in the press release. “We have developed a solution geared toward data engineers, with innovative features to help data teams manage the increasing volume and complexity of data”, he adds.

biGENIUS AG was founded in 2021 as a spin-off from the IT service provider Trivadis, which is based in Glattbrugg in the canton of Zurich and has since been taken over by Accenture. The startup from Pratteln specializes in the development of analytical data automation solutions. The company explains in the press release that the new biGENIUS-X solution was developed independently of the established Windows application biGENIUS 7, which has been available since 2011.

New CEO on board

In the same press release, biGENIUS also communicates a change at board level. Accordingly, Gerald Klump was appointed as the new CEO with effect from October 2. The former co-CEO of Trivadis, who was later the Managing Director of Accenture DACH, succeeds Gregor Zeiler as CEO of biGENIUS.

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AI for SMEs – The complete guide to implementing AI in your manufacturing company https://baselarea.swiss/blog-post/ai-for-sme/ Mon, 26 Jun 2023 11:27:22 +0000 https://baselarea.swiss/?post_type=blog_post&p=150371 Over 3 years, we developed a guide to implementing AI in your manufacturing company. Learn about our progress and be the first to get the AI4SME Guide.

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AI for SMEs – The complete guide to implementing AI in your manufacturing company

A 2022 study revealed that 97% of companies recognize the advantages of AI, especially in optimizing internal processes. But only 1 in 10 use it.

To help others get started, we’ve compiled the AI4SME Guide over the last three years.

It’s made for manufacturing SMEs interested in implementing AI in their operations. Whether you’re at the initial stages of considering AI implementation or seeking guidance to optimize existing AI initiatives, this guide provides practical advice and recommendations tailored specifically to manufacturing SMEs.

DOWNLOAD THE GUIDE

Meet your industrial transformation partner

The production industry is a significant economic sector in the Basel Area. To help companies succeed, we bring together stakeholders from industry, academia and startups to collectively advance innovation in the field of Industry 4.0.

To learn more about our Industrial Transformation Initiative, visit our website.

We want to help you prepare your company for the future

The skills we need in the future will be different than today. Every company has to explore what those skills will be and how they can be integrated before it’s too late.

Domenico ScalaPresident, Basel Area Business & Innovation

Imagining the future enables us to act now. AI is here to stay, but few SMEs have been bold enough to implement AI in their processes. Many don’t feel the need to transform. Meanwhile, the world around them keeps turning, eventually leaving them behind.

Besides missing resources and high skepticism around AI, we’ve found that many companies have difficulties finding their way into the AI world because AI projects are perceived as complex. An AI project requires a broad field of competencies.

Three years ago, we started working on a standardized process that would allow SMEs to quickly develop AI solutions and implement them in their manufacturing processes.

We called it the AI4SME Program.

From the start, we knew that collaboration was the key to innovation. We brought together our industry partners, active experts and community members and secured governmental support (NRP) to exchange ideas, share experiences and encourage one another.

With our combined knowledge, we’ve helped eight companies — two of which you’ll meet later in this article — to design and develop a proof of concept for an AI project that can meaningfully transform their businesses.

We still continue to support SMEs that reach out to us in their development of AI solutions. But to make our findings available to everyone, we turned what we learned throughout the AI4SME Program into the AI4SME Guide.

AI4SME Guide — A step-by-step guide to implementing AI in manufacturing SMEs

The AI4SME Guide is your first step to implementing AI in your manufacturing SME. It contains the combined knowledge our partners and us have gained in the past three years of developing AI projects.

 

The AI4SME Guide…

• provides insights on the need for innovation in manufacturing SMEs.
• helps you determine the relevance of AI adoption for your SME.
• contains information about support options in the Basel Area.
• addresses progress blockers like skepticism, resource limitations and uncertainty.
• gives step-by-step instructions to start your AI journey.
• explores the do’s and don’ts when implementing AI in a business.
• showcases inspirational success stories.
• links sustainability and AI.
• showcases future technologies.
• summarizes goals, successes, and learnings from the AI4SME Program.

The two following companies have gone through the AI4SME Program to develop a proof of concept for their AI project that can meaningfully transform how they operate.

KETAG uses AI to enhance energy efficiency

Küffer Elektro-Technik AG has more than 70 years of experience in auditing, repairing and improving drive systems of all kinds.

Through AI4SME workshops, KETAG developed an app called TSapp. It makes it easy for workers to find the most suitable and energy-efficient replacement electric motor.

According to EnergieSchweiz, electric motors consume about 20% of Switzerland’s electricity. Due to a lack of expertise and time pressure, broken motors get replaced by the same models instead of more energy-efficient ones.

With TSapp, anyone can scan the data of a motor embossed on its type plate. A matching algorithm compares this information with the IEC standard and automates the search for a suitable new motor. A corresponding list of recommended electric motors is provided, and thanks to the interconnection of suppliers, ordering them is quick and easy.

The solution is independent of the manufacturer and can read type plates of various ages up to 40 years old.

Liebherr-France uses AI to improve operational efficiency

The Liebherr Group is a Swiss conglomerate known for its diverse range of products, including construction machinery, aerospace components, and domestic appliances.

Through AI4SME workshops, Liebherr developed a solution for the early detection of dysfunctions in their production machines.

Production machines sometimes break down. When that happens, they need to be repaired, which costs money and creates downtime in production. Liebherr found that in around 5% of cases, spare parts are missing, which delays immediate repairs.

To anticipate failure, Liebherr identified collecting more (and the right) data as key.

Liebherr uses various sensors to record all relevant machine variables. The collected data is stored on a server hosted by Liebherr and accessible through a secure connection.

As a result, Liebherr prevented a lengthy machine shutdown in a quick intervention that lasted only 10 minutes.

Summary: AI4SME at a glance

Get the full AI4SME Guide

 

In the last three years, we’ve helped eight companies to develop a proof of concept for an AI solution that could meaningfully transform their businesses. We brought together stakeholders from private individuals to companies and governments over three nations to exchange knowledge and innovate together.

The full AI4SME Guide contains all the information you need to develop and implement AI in your manufacturing SME.

Download the guide

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Sébastien Meunier Director Industrial Transformation.

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Sébastien MeunierDirector Industrial Transformation

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QuantumBasel offers access to the world’s most powerful quantum computers https://baselarea.swiss/blog-post/quantumbasel-offers-access-to-the-worlds-most-powerful-quantum-computers/ Fri, 23 Jun 2023 12:53:12 +0000 https://baselarea.swiss/?post_type=blog_post&p=150242 QuantumBasel has consolidated its status as a neutral quantum hub with access to the world’s best quantum computers through a partnership with the North American quantum computer manufacturer IonQ. In addition, IonQ is building its innovation center for the EMEA region in the Basel Area.

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QuantumBasel offers access to the world’s most powerful quantum computers

23.06.2023

QuantumBasel has consolidated its status as a neutral quantum hub with access to the world’s best quantum computers through a partnership with the North American quantum computer manufacturer IonQ. In addition, IonQ is building its innovation center for the EMEA region in the Basel Area.

Handshake after signing: Noam Zakay, Peter Chapman, Thomas Staehelin, Karl Gun and Damir Bogdan (from left to right) (image: QuantumBasel)

QuantumBasel, the competence center for quantum and Artificial Intelligence (AI), is bringing a physical quantum computer from the Maryland-based manufacturer IonQ to Switzerland. From 2024 onwards, it will be the first commercially usable quantum computer at the uptownBasel site in Arlesheim in the canton of Basel-Landschaft. QuantumBasel is part of the uptownBasel Group, whose partners also include the investment and innovation promotion agency Basel Area Business & Innovation.

In specific terms, two generations of quantum computers will be installed on site, further details of which can be found in a press release issued by all partners. The first, with 35 algorithmic qubits (#AQ 35), is expected to surpass the capabilities of quantum simulators on classical computers. This computer will later be replaced by the next generation with 64 algorithmic qubits (#AQ 64). Even the best conventional supercomputers should no longer be able to compete with this.

Innovation center in the Basel Area

In addition, the development of the #AQ 64 partly took place in Switzerland. After all, IonQ intends to set up its innovation center for the entire EMEA region at the campus in Arlesheim. Following IBM and D-Wave Systems, QuantumBasel has now also been able to secure the services of IonQ as a partner. Peter Chapman, CEO of IonQ, describes this in the press release as a “historic deal for IonQ and the quantum industry”, adding that: “This is the system that companies have been waiting for. We are glad that QuantumBasel is joining us on this journey”.

“The deployment of IonQ systems on site will accelerate and enhance our pursuit of quantum innovation and further our goal of achieving breakthroughs”, comments Dr. Thomas Staehelin, investor and Chairman of the Board of uptownBasel, in the press release. With these systems, uptownBasel expects to attract additional innovation companies to the region.

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How digital transformation is driving pharmaceutical innovation in Basel https://baselarea.swiss/blog-post/pr-digital-transformation-driving-pharmaceutical-innovation/ Wed, 21 Jun 2023 12:48:19 +0000 https://baselarea.swiss/?post_type=blog_post&p=150340 How are digital innovations such as artificial intelligence and machine learning helping to improve drug research and development? Digital technologies – such as artificial intelligence, natural language processing and data analytics – are revolutionising healthcare by helping medical professionals to make better, more informed decisions, as well as by accelerating the discovery of new therapies.

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How digital transformation is driving pharmaceutical innovation in Basel

21.06.2023

How are digital innovations such as artificial intelligence and machine learning helping to improve drug research and development? Digital technologies – such as artificial intelligence, natural language processing and data analytics – are revolutionising healthcare by helping medical professionals to make better, more informed decisions, as well as by accelerating the discovery of new therapies.

These advancements promise to propel healthcare into the future and make the seemingly impossible possible, including everything from optimizing patient care through robust data analytics, to aiding the discovery of complex disease patterns through artificial intelligence (AI) algorithms. This article features some examples of digital technology, which are supporting pharmaceutical R&D in the innovative science hub that is the Basel Area, Switzerland, and describes how these latest developments will play a major role in the ever-changing healthcare landscape.

New Platforms for Drug Discovery

The pharma industry continues to be driven by the need to refresh pipelines, identify new targets, design new drug molecules and find new biomarkers for successful clinical development. With the days of ‘low-hanging fruit’ and serendipitous drug discovery in the past, new platforms are required to provide data-based solutions in R&D. AI, ML and other digital technologies can allow companies to benefit from large datasets that have been captured in recent years, including drug molecule libraries, genomic data, patient health records and medical imaging data. These different platforms have applications across the drug discovery and development process. Some enhance existing computational library screening efforts to identify drug-like molecules with very specific properties that would not be found with traditional methods; others highlight biomarkers of disease progression in electronic health records, feeding into both target discovery and clinical trial design. By tapping into the huge quantities of data that are now available, pharma companies can develop new drugs quicker and with an improved chance of success. Recent research suggests that even modest improvements in early-stage drug development success rates enabled by AI and machine learning (ML) could lead to an additional 50 novel therapies over a ten year period, translating to more than $50bn in opportunities.1

Partnering for Innovation

Much of the innovation in this field has been driven by AI-native companies offering products or services through partnerships or software licensing deals that can then be applied to pharma pipelines. The move from traditional service and software models to the use of asset and pipeline development partnerships has led to soaring investment. Figures show that third-party investment in AI-enabled drug discovery has more than doubled annually for the last five years, topping $2.4bn in 2020 and reaching more than $5.2bn at the end of 2021.2

Health Tech Boom in Basel

One area where this synergy between digital technology and pharmaceutical R&D is making waves is the Swiss city of Basel, where a leading European innovation hub has grown to be the home of over 700 companies across the biotechnology, digital health, medical technology, chemistry and advanced manufacturing sectors. This includes pharmaceutical giants such as Roche, Novartis, Johnson & Johnson and Boehringer Ingelheim. Companies continue to flock to the Basel Area to take advantage of the world-class academic institutions and local talent pool of over 31,000 life sciences professionals, as well as the network of big pharma juxtaposed with scaleups and startups. Amongst the most recent arrivals are health tech companies looking to support R&D in the big pharma arena. For these companies, a presence in the region provides the perfect opportunity for meeting, networking and developing new relationships that are crucial for further innovation. Several companies are making the most of the thriving tech culture, supporting initiatives for health tech startups and dedicated innovation and co-working spaces, to drive success in the Basel Area.

Discovering Complex Disease Patterns

Examples of the work being performed include:

  • Associating multimodal single-cell datasets (RNA-/TCR-/ BCR-seq, proteomics, etc) with clinical endpoints – such as disease diagnosis, progression, severity, treatment and toxicity response – to identify ultra-sensitive biomarker signatures and cell functionality states
  • A research engine that introduces a new standard of interpretability and explainability to life sciences datasets using simple models and straightforward mathematical expressions to help pharma companies bring drugs to market faster
  • AI-powered analytics and digital solutions to support improvements in behavioral health, delivering rich, high-quality and relevant real-world evidence information to healthcare providers, patients, researchers, payors and regulators by analyzing electronic health record data with analytics. This data helps providers recognize disease progression and provide tailored treatments to their patients, and aids pharmaceutical companies in improving drug discovery and development.

The Future of Digital Innovation in Pharma

The applications above are classic examples of how digital technologies can make use of the vast quantities of data that are being generated in healthcare and pharmaceutical R&D. Their innovative products and services are allowing new insights and a deeper understanding of complex processes – including disease progression, drug mechanisms of action and clinical effectiveness of new drug candidates – and they are improving the drug development process. The platforms themselves are driving a paradigm shift that could enhance the process of drug discovery, bringing new drugs to market more quickly, and reducing the large numbers of candidates that are currently lost along the development pathway. Strong partnerships between technology and pharma companies, academic institutions and hospitals, such as those being developed in Basel, are undoubtedly helping to revolutionize the future of healthcare.

References

    1. Morgan Stanley Research (2022), ‘Putting the ‘Tech’ in Biotech: Assessing the Potential for AI in Drug Development’
    2. Boston Consulting Group (2022), ‘Adopting AI in Drug Discovery’

Article by

Frank Kumli
Head of Innovation & Entrepreneurship, Basel Area Business & Innovation

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Medical informatics is shaping Switzerland’s digital future https://baselarea.swiss/blog-post/medical-informatics-is-shaping-switzerlands-digital-future/ Thu, 15 Jun 2023 09:00:21 +0000 https://baselarea.swiss/?post_type=blog_post&p=150246 Switzerland is at the forefront of embracing medical informatics, and innovative biotech hubs – such as the Basel Area – are proving fertile ground for private companies and academic institutions looking to forge a shared digital destiny. This article takes a look at how Switzerland is cultivating cross-fertilisation between the data analytics and medical fields to establish itself as a nation of truly digital healthcare.

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Medical informatics is shaping Switzerland's digital future

15.06.2023

Switzerland is at the forefront of embracing medical informatics, and innovative biotech hubs – such as the Basel Area – are proving fertile ground for private companies and academic institutions looking to forge a shared digital destiny. This article takes a look at how Switzerland is cultivating cross-fertilisation between the data analytics and medical fields to establish itself as a nation of truly digital healthcare.

Published by the Journal of mHealth

We are generating more digital data than ever before – at an estimated rate of 2.5 quintillion bytes per day1 – and the great strides being made in informatics are helping to excavate ever-more meaningful and actionable information from these data goldmines. Tools like artificial intelligence and machine learning could hold the key to transforming a whole host of sectors, but perhaps none more so than healthcare, where game-changing technologies are under development.2

Building on a rich heritage

Several regions of Switzerland are well known for being bustling biopharma hotspots. The Basel Area in particular is home to industry giants including Roche, Novartis and Johnson & Johnson, as well as many smaller companies that are taking advantage of both the world-class academic institutions and the swathes of life science professionals embedded there. Below the surface of this rich biotech and pharmaceutical heritage is a new wave of digital innovation that has the potential to transform the healthcare industry, and Switzerland along with it. A new breed of entrepreneurs is combining biopharma knowledge with medical informatics to promise a digital healthcare revolution.

Laying the groundwork

It is no coincidence that this transformation is happening in Switzerland, since academic institutions like the University of Applied Science and Arts Northwestern Switzerland (FHNW) have been laying the groundwork for years, by offering forward-thinking medical informatics courses.3 These multidisciplinary degrees are moulding medical, data science and business students into fully-fledged medical informatics experts ready to make their mark on the industry.

aiHealthLab is focused on the emerging field of artificial intelligence in healthcare. We use machine learning to process large amounts of data – obtained through collaborations with hospitals and pharmaceutical companies – to gain insights that can support drug discovery, aid the understanding of complex biological mechanisms, and guide the development of clinical support systems for precision diagnostics. The Master of Science in Medical Informatics program has been a game changer for us. Traditionally, the aiHealthLab would be forced to take on either informatics students with no knowledge of immunology, or medical students with no experience in data science, making it a steep learning curve for new researchers. Now, we have a selection of well-rounded candidates to pick from, and no longer have to compromise.

Prof. Enkelejda MihoHead of the Laboratory of Artificial Intelligence for Health (aiHealthLab) at FHNW

Prof. Miho is also the founder of the ETH Zürich spinout company aiNET – based in Basel – which uses artificial intelligence and large-scale networks to provide immunoinformatic services for the biopharma industry, as well as digital immunity data to aid personalized diagnostics. She continued: “We offer an antibody discovery service via high-throughput sequencing of immune cells and antibodies, using machine learning techniques to select sequences that successfully bind to viruses. We are also developing a digital twin of the human immune system, which evolves over time to mimic the dynamic nature of the real thing, allowing us to accurately model and predict disease progression to enable early diagnosis. We feel extremely lucky to be based in Basel, where there is a healthy collaborative spirit between academics, clinicians and biopharma professionals. There is a true culture of innovation here.”

Help is at hand

Launching a startup like aiNET can be a daunting prospect, as many startups fail within their first year.4 Switzerland is determined to buck this trend by fostering a supportive environment where fledgling companies offering cutting-edge innovation can thrive. Not only is there tax relief for startups, but organisations like Innosuisse and the Swiss National Science Foundation provide grants to help academic researchers and entrepreneurs commercialise their promising ideas, as well as promoting the activities of regional startups and SMEs. Accelerator and incubator programs are also available to provide startups with legal and logistical support, extra investment, and access to a network of experienced biopharma professionals. For example, The Digital Health Nation Innovation Booster program, hosted by DayOne and Innouisse, is fostering breakthroughs in digital healthcare by helping entrepreneurs transform their ideas into solutions that can deliver real value to patients and healthcare professionals. Basel Area Business & Innovation – the non-profit innovation promotion agency behind DayOne – also manages dedicated coworking sites that foster a thriving interactive community of digital health companies and entrepreneurs, such as the Switzerland Innovation Park Basel Area at the Novartis Campus.

Our innovation council has chosen to fund the Innovation Booster in order to identify and promote radical digital healthcare technologies that are likely to have a significant market impact. The successful applicants receive the funding they need to bring their big ideas to life, while mitigating some of the financial risks inherent in early product development. The success of this program is down to the team of experts from DayOne, which provides valuable expertise, logistical support, extra investment and access to its network of industry professionals.

Emile DupontKnowledge and Technology Transfer Team Leader at Innosuisse

Switzerland’s digital destiny

Cutting-edge tools like AI and machine learning are set to revolutionise healthcare by generating remarkable insights from medical data and making previously unimaginable technologies – like immune system digital twins – a reality. By combining multidisciplinary degree programs, governmental support and accelerator and incubator programs, Switzerland is laying the groundwork needed for digital healthcare to flourish. Its thriving biotech hubs are an ideal breeding ground for a new era of startups, and the potent combination of biopharma heritage and novel technologies is set propel Switzerland towards its digital destiny.

References

Article by

Frank Kumli
Head of Innovation & Entrepreneurship, Basel Area Business & Innovation

Valentina Francia
Manager of International Markets & Business Affairs, Basel Area Business & Innovation

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Genedata expanding its user network https://baselarea.swiss/blog-post/genedata-expanding-its-user-network/ Tue, 06 Jun 2023 13:53:28 +0000 https://baselarea.swiss/?post_type=blog_post&p=150203 The Japanese biopharmaceutical firm Ajinomoto is to use the Genedata solution to accelerate its drug development processes at its site in South Korea as well. The location in China is set to follow suit in due course. Other pharmaceutical firms are also increasingly turning to the IT solution developed in Basel.

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Genedata expanding its user network

06.06.2023

The Japanese biopharmaceutical firm Ajinomoto is to use the Genedata solution to accelerate its drug development processes at its site in South Korea as well. The location in China is set to follow suit in due course. Other pharmaceutical firms are also increasingly turning to the IT solution developed in Basel.

Ajinomoto is to integrate Genedata Bioprocess at its research and development locations in Japan and South Korea. The Japanese biopharmaceutical firm is using the solution developed by the Basel-based IT company Genedata, which specializes in the life sciences sector, as a central data backbone to streamline cell culture media development and production operations, including in regulated environments, further details of which can be found in a press release issued by Genedata.

Ajinomoto has been using Genedata Bioprocess in Japan for around a year now. “The platform integrates with our existing laboratory instrumentation, allowing us to evaluate huge volumes of cell culture media development data at a level of complexity that was previously unimaginable”, comments Hiroyuki Mise, General Manager Biopharma Solutions Group, Amino Acids Department at Ajinomoto, in the press release. Use of the solution is now being expanded to the teams in South Korea to facilitate cross-site projects. There are also plans to include the company’s location in China in the future.

More customers acquired

“I am delighted to see that Ajinomoto is expanding the usage of Genedata Bioprocess across its Asian development and manufacturing sites, which is how we envision our platform to be used,” says Othmar Pfannes, CEO of Genedata, headquartered in Basel.

It was only in May that Debiopharm decided to use the Genedata Profiler. It allows the Lausanne-based pharmaceutical firm to quickly convert scientific findings into therapeutic products, thereby improving the success of clinical trials. In December, Genedata announced that Icosagen Cell Factory in Estonia would be using Genedata Biologics to digitize and automate its recombinant antibody discovery services. In October 2022, the French firm Sanofi also opted to use Genedata Biologics at additional research and development sites.

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AI engineering and its impact on business https://baselarea.swiss/blog-post/ai-engineering-and-its-impact-on-business/ Wed, 17 May 2023 13:27:05 +0000 https://baselarea.swiss/?post_type=blog_post&p=149563 Learn how AI is changing the game of innovation, its role in product development and what companies have to do to not get left behind.

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AI engineering and its impact on business

In our 11th iteration of the Technology Circle (15.03.2023), we learned about AI’s role in the production business today and its potential role in the future.

Our four speakers talked about how AI is changing the game of innovation, its role in product development and what companies have to do to avoid falling behind.

Talk to us

Inventing in the era of computerization using TRIZ and AI

Prof. Denis Cavallucci, Professor in Engineering of Innovation at INSA Strassbourg, kicked off the event with a presentation about the most appropriate way to combine human intelligence with digitally assisted invention using TRIZ theory.

We’re facing industrial challenges of highest importance. CO2 neutrality, hydrogen, quantum and feeding the planet are only some of the many areas we’re working on. How we manage to overcome those hurdles depends on the brave problem solvers of our time.

Denis proposes we need to enhance the capabilities of every single problem solver with the power of AI. The web is a vast, ever increasing sea of data. According to recent statistics, it holds 170 million patents, containing about 80% of humanities technical knowledge. Every 1.5 minutes, a new patent gets added. There’s also a new scientific article every 15 seconds and 570 serious websites every minute 0% of the world’s digital data has been created in the last 3 years. All this data could be used to formulate and solve problems. Because no person can read that much, we have to automate the process. That’s where TRIZ comes into play.

What TRIZ is and what it can do
TRIZ is an acronym for Theory of Inventive Problem Solving. Denis summed it up like this:

“TRIZ is a common way of observing problems and shareable solutions through underlying principles. If you can share problems and solutions across disciplines, you may be able to formulate the problem in one discipline and then solve it in another.”

Denis and his team applied the principles of TRIZ to unstructured content to turn any text into usable logic for idea generation.

I = Pb + D

To explain what automatic idea generation means, Denis proposes the hypothesis that an idea is the addition of a problem and data that could solve it.

  • I: The result of human interpretation.
  • Pb: A problem transformed into a contradiction.
  • D: Data extracted from trustful content.
  • +: The transdisciplinary pairing of problem and data.

If you bring an engineer a correctly formulated problem and the appropriate data, they can generate ideas to solve it.

To facilitate and ultimately automate this process, Denis and his team built the AIARD  Industrial Chair.

The goal is building a set of intelligent tools that accompany users, real time, from expressing their problem to the most relevant scientific information likely to solve it.

Introducing Forvia

Sébastien Trillat, Innovation Global Domain Manager at Forvia, introduces his company and explains why they partnered with the AIARD Industrial Chair. Forvia is a leading global automotive technology company. It’s based on the long-established company Faurecia and is the 7th global automotive supplier.

A few years ago, Sébastien wanted to start working with TRIZ. Forvia partnered with AIARD Industrial Chair to train its employees in the TRIZ methodology. Soon, Forvia saw the potential benefits of dedicating resources specifically to the methodology. That’s when the company hired a young engineer to develop an internal network on TRIZ. Meanwhile, Forvia is already implementing many TRIZ principles to reap the benefits early on. And with great success! A tool they’ve developed together with AIARD Industrial Chair is expected to bring benefits in the double-digit millions.

AI for business leaders—from zero to hero in product development

Prof. Dr. Bernhard Kölmel from the Hochschule Pforzheim & WFG Wirtschaftsregion Nordschwarzwald taught us how decision makers can implement AI in their organizations. He started with a quote from Lord of the Rings.

The world has changed. I see it in the water. I feel it in the earth. I smell it in the air. Much that once was is lost, for none now live who remember it.

Lord of the Rings

ChatGPT has created a lot of hype around AI. It’s an important topic and experts say that while the hype is at its peak, they don’t expect a bust following it. It’s important to see the big picture. ChatGPT-4 is very impressive but the competition isn’t sleeping. China, for example, has developed a language model even larger than ChatGPT-4! AI is also becoming even more interesting thanks to the Internet of Things (IoT). Almost every machine — even fridges and toasters — collect data that we can use to formulate problems and find solutions.

Companies aren’t used to dealing with easily accessible AI yet. Many think that there are dangers to AIThey try to find these “AI heroes” with the idea of trusting them on every business decision that involves AI. We need to demystify AI and get rid of the “heroes”. Bernhard made a great example why it’s so important.

It takes experts to repair planes, ships and helicopters. Just because those experts know the vehicle inside and out, doesn’t mean they can run the fleet.

Prof. Dr. Bernhard Kölmel

Every decision maker needs to be competent in making AI-involving decisions. AI projects are more than a code. According to a 2014 research paper by Google, only 3% of all AI activities are about the algorithm. The rest is about the work that needs to be done around the algorithm.

Figure: only a small fraction of real-world ML systems is composed of the ML code, as shown by the small black box in the middle. The required sorrounding infrastructure is vast and complex.

Al technologies are complex and relatively new to the business world. Few decision makers understand them. To truly unlock the value of Al, you have to fully integrate it into the fabric of your company. That requires strategies and approaches that understand the science behind AI, the techniques to implement it and the right metrics to measure it’s success. It’s necessary for every company to develop an AI strategy, broken down into concrete, measurable goals. A few examples of AI successfully improving new product development

Bernhard introduces three examples to showcase the power of AI in product development.

  • The Volkswagen Group is using Al to improve the efficiency of its production processes. The company has developed an Al system that uses data from the production process to predict quality defects and improve the production process. This has resulted in significant improvements in production efficiency and reduced defect rates.
  • Siemens is using Al to optimize the design of its products. The company has developed an Al platform that uses machine learning algorithms to analyze data from product simulations and tests. This has helped Siemens to optimize product designs, reduce development time, and improve product performance.
  • Bosch is using Al to develop new products. The company has set up an Al research center that focuses on developing Al-powered products, such as smart home systems and autonomous vehicles. This has helped Bosch to diversify its product portfolio and stay ahead of the competition.

To decide on what AI project your company should work on, Bernhard recommends the AI Project Canvas, modelled after the famous Business Model Canvas. Here is where you can find it with a detailed explanation:

Getting better on your own — Automatic optimization of advanced robotic applications

Dr.-Ing. Darko Katic from ArtiMinds GmbH in Karlsruhe showcased how ArtiMinds uses AI to realize the full potential of advanced robotics. Darko puts his company’s mission simply:

We create software to program robots more easily in all stages of robotic applications: planning, programming, installation, deployment, analysis and optimization.

Dr.-Ing. Darko Katic

To do that, ArtiMinds has two solutions. First, the Robot Programming Suite (RPS) enables developers and process experts to program industrial robots in an easy, intuitive fashion. Second, the Learning & Analytics for Robots (LAR) collects all data coming from a robot and helps analysts interpret it in a meaningful way.

Currently, a lot of manufacturing happens in low income countries. There’s a risk to that as we’ve seen with the pandemic or the war in Ukraine and the respective production issues. We need to bring production back into our own country. The only way to match the cheap labour cost is by using advanced robots.

Robots are very good if they can repeat the same task over and over again without having to adjust to anything. In reality, manufacturing isn’t that easy.

  • No two work pieces are the same: there might just be a mm difference between them, impossible to see with your naked eyes. If a piece doesn’t fit, we adjust it intuitively. A robot can’t.
  • Something might be “broken”: if a pin on a circuit board is slightly bent, the robot can never fit anything on it. A human would just bend the pin back.
  • Not all pieces are rigid: cables, for example, might fall in a weird position or even tangle up. While a human can untangle them easily, a robot can’t work with them anymore. Those are just three of the many challenges we’re facing in advanced robotics.

The robot needs to be able to understand the problem. With sensors, the robot can see and feel the parts its working with. Almost like a human would. If, for example, it needs to insert one piece into another, it’ll register resistance if the pieces don’t fit. It’ll then adjust the position until there is no resistance anymore. With lasers and cameras, the robot recognizes the parts and their positions to adjust itself, making it possible to automate the production with cables and tubes.

It’s fairly easy to make these solutions work in a controlled setting. But getting them production-ready is a different story. That’s why we introduced data driven analysis and optimization. Everything the robot does generates data which we can attribute to a specific action. We collect and visualize this data to make it possible for engineers to easily identify flaws and mend them. A mistake can take only milliseconds and nanometers. An engineer needs the visualization of the data to see it.

Our AI already generates possible solutions to the problems for the engineers to simply verify and implement. The next goal is to enale the robot to learn from its mistakes and make the adjustments itself with the help of a digital twin.

Let us introduce ourselves

The Industrial Transformation initiative: Realize digital transformation in your company.

The production industry is a significant economic sector in the Basel Area. To help companies succeed, we bring together stakeholders from industry, academia and startups to collectively advance innovation in the field of Industry 4.0.

Our Industrial Transformation team’s activities include:

  • A series of public events for the industry dedicated to technologies important for the innovative development of our tri-national region.
  • Promote cooperation between entrepreneurs and academia.
  • Technology circles Industry 4.0 Events and workshops on Industrial transformationIoT and advanced technologies for digital transformation.
  • An AI4 and SME program for the collective and concrete development of Proofs of Concept with Artificial Intelligence Innovative solutions for the production industry.
  • The i4Challenge accelerator for SMEs, startups and new ideas for Industry 4.0.

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Sébastien Meunier Director Industrial Transformation.

Sébastien Meunier joined Basel Area Business & Innovation in 2016. Prior to this, he was Cleantech Manager at i-net innovation networks switzerland.

Are you interested in innovation and networking? In our Trinational Industry 4.0 Technology Circles we bring together researchers, developers, entrepreneurs and other stakeholders for cross-disciplinary exchange.

Sébastien MeunierDirector Industrial Transformation

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Clinerion is now part of Citeline https://baselarea.swiss/blog-post/clinerion-is-now-part-of-citeline/ Thu, 02 Feb 2023 15:48:14 +0000 https://baselarea.swiss/?post_type=blog_post&p=147348 Clinerion has been integrated into New York-based company Citeline. Clinerion plans to expand its portfolio with Citeline’s complementary opportunities with regard to drug development acceleration. Clinerion’s headquarters are to remain in Basel.

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Clinerion is now part of Citeline

02.02.2023

Clinerion has been integrated into New York-based company Citeline. Clinerion plans to expand its portfolio with Citeline’s complementary opportunities with regard to drug development acceleration. Clinerion’s headquarters are to remain in Basel.

Clinerion’s CEO Barış Erdoğan has officially announced that the company is now part of Citeline, a leader in clinical trials. The company based in New York, which formerly operated as Pharma Intelligence, merged with Norstella from the US state of Pennsylvania at the end of 2022. This means that the Norstella Group now comprises five companies: Evaluate, MMIT, Panalgo, The Dedham Group, and Citeline.

The new pharmaceutical technology company with more than 1,600 employees across the world is now one of the world’s largest providers of pharma information solutions on the market. According to a press release from Norstella, it is currently valued at 5 billion US dollars. It aims to enable smooth access to life-saving therapies for those with illnesses by accompanying life science companies throughout the entire drug development process.

Clinerion’s headquarters remain in Basel

According to a personal message from Clinerion’s CEO, its integration into Citeline provides the opportunity to access tools and services that each supplement the other’s, thus expanding the product portfolio. Furthermore, Clinerion will gain access to specialists and expertise along the entire process chain from clinical intelligence, planning, development, and studies. This is why the merger with Citeline and the Norstella Group is “excellent news” for partners and customers. Clinerion’s headquarters will remain in Basel.

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Digital twins and data visualization in Industry 4.0 https://baselarea.swiss/blog-post/digital-twins-and-data-visualization-in-industry-4-0/ Wed, 18 Jan 2023 08:20:08 +0000 https://baselarea.swiss/?post_type=blog_post&p=146849 We invited five speakers to talk about digital twins, data visualization and the Building Information Modeling (BIM) used in the Lausanne train station renovation project.

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Digital twins and data visualization in Industry 4.0

The question of our latest Technology Circle (15.11.2022) is simple: How can we translate data to actionable insights and implement them efficiently? And why is it important to do it?

We invited five speakers to talk about digital twins, data visualization and the Building Information Modeling (BIM) used in the Lausanne train station renovation project.

The digital twin

Prof. Markus C. Krack from FHNW Brugg-Windisch told us what a digital twin actually is (and what it isn’t) and what it’s used for in the real world.

In the future, everything might exist twice. Each real object might have its virtual counterpart. Those virtual counterparts are more than just copies. They are directly linked and synchronized with the physical twin, influencing each other.

Digital twins are a hot topic. Many are talking about the concept, but few know what a digital twin really is. There is a clear-cut definition.

A digital twin is a virtual image of a physical object that can receive information from its physical counterpart and send information back to the real object in real-time.

Prof. Markus C. Krack

A CAD drawing is not a digital twin. A virtual replica isn’t a digital twin, either. It’s only a digital twin when both sides are connected and communicate.

The first real application of a digital twin came from NASA. For a space mission, NASA created the flying twin to mirror the space object in real-time.

Its computing and simulation power predicts what could happen to the real-world object under certain circumstances. Based on the digital twin’s calculations, it also makes decisions for the real object.

Three kinds of digital twins

We distinguish between the product twin, the production twin and the performance twin.

The product twin is a virtual replication of a real product. It uses data from the real product to quickly and effortlessly test various use cases and situations.

The production twin replicates a manufacturing system to supervise and support production. If it detects anomalies, it can quickly decide whether to stop production before something overheats, for example.

The performance twin is also called the digital memory of a product. It can map things like production key figures, quality characteristics and processing times to predict and improve the performance of its physical twin.

Today, we use digital twins for a variety of purposes like:

  • Manufacturing improvement. We respond to changes in production conditions in real-time by simulating the process.
  • Risk management. The measured data from the equipment can be used to detect irregularities and predict possible failures.
  • Process optimization. This can show potential for improvement of the process, allowing automatic optimization by AI.

A real digital twin today: the Lausanne train station reconstruction

Jan Reifler and Mathias Kuhn from Basler & Hofmann presented the intricate project of the Lausanne train station reconstruction.

Lausanne is beautifully located at Lake Geneva, well known for its landscape and is on the UNESCO world heritage list. It’s part of a dynamic region that continues to develop strongly with above-average growth in population.

The number of travelers between Geneva and Lausanne has doubled between 2000 and 2010 and is expected to double again in the next ten years.

To prepare for this growth, the Lake Geneva region is implementing project Léman 2030.

The plans to build out the Lausanne train station as part of Léman 2030 include widening the platforms, demolishing certain buildings, extending the underpasses and much more. A huge undertaking.

The crazy thing is, the new train station already exists!

The Lausanne train station project is a BIM pilot project of the Swiss Federal Railways SBB with a complete data model of the station.

A huge advantage of this approach is that one single source of truth exists. SBB can use the 3D model, for example, to generate 2D formwork and reinforcement plans.

Creation of formwork plans using BIM data.

Creation of reinforcement plans using BIM data.

One thing needs to be demolished and another thing needs to be built in its place. It’s quite the challenge to coordinate that for hundreds of instances.

Using AI, SBB could transfer the time data to the digital twin, which then processes the information and creates a construction and demolition sequence.

In the future, every building, every bridge and every road could have its digital twin. To get there, we need standardized processes and tools on which we are currently working.

Modern data visualizations: more than colors and bars

Manuel Werner and Caspar von Stülpnagel from b.telligent GmbH showed some interesting example cases from Microsoft’s Swiss Championship Challenge 2022.

Back in the day, people used to report data mostly with tables. This only lets us see figures. As visual creatures, it took us a long time to understand data presented that way.

In the next step, we started visualizing data in graphs. That was a step up from sheer numbers but it lacked interaction. Although the data was easier to understand, we could only see what the analysts wanted us to see.

Today, the world of data visualization is different.

The “best report of the world” (yes, there is actually an award for that) looks like this. It excels in two important principles: design and gamification.

The importance of report design

Reports are not just numbers and graphs anymore. They’re designed as applications you can interact with. If you access the report above, you’d intuitively know how to find the data point you need. It uses natural eye movement patterns to guide you to the most important figures and functions and generates conclusions in text form that help you easily understand the data.

The importance of gamification

The interactive component of the report makes it possible to add gamification elements. This binds the consumer inside the reports and lets them decide — based on your rules — what data they see and how.

Let us introduce ourselves

The Industrial Transformation initiative: Realize digital transformation in your company.

The production industry is a significant economic sector in the Basel Area. To help companies succeed, we bring together stakeholders from industry, academia and startups to collectively advance innovation in the field of Industry 4.0.

Our Industrial Transformation team’s activities include:

  • A series of public events for the industry dedicated to technologies important for the innovative development of our tri-national region.
  • Promote cooperation between entrepreneurs and academia.
  • Technology circles Industry 4.0 Events and workshops on Industrial transformationIoT and advanced technologies for digital transformation.
  • An AI4 and SME program for the collective and concrete development of Proofs of Concept with Artificial Intelligence Innovative solutions for the production industry.
  • The i4Challenge accelerator for SMEs, startups and new ideas for Industry 4.0.

Industrial Transformation is a initiative from Basel Area Business & Innovation

Basel Area Business & Innovation is a non-profit investment and innovation promotion agency on a mission to establish the Basel Area as the Swiss business and innovation hub of the future.

The Basel Area is the name of the economic region of Basel-Stadt, Basel-Landschaft and Jura. Companies, institutions and startups that want to explore business opportunities here can profit from our services in three main categories:

  • Invest: We help foreign or outer-cantonal businesses set up and find footing in the Basel Area.
  • Innovate: We mentor and accelerate companies in the Basel Area that focus on life sciences and industry 4.0.
  • Switzerland Innovation Park: We offer four locations with fully equipped labs and office space for collaborative innovation.

Our new Main Campus

Welcome to 50’000 m² of interconnected innovation space. As part of the most dynamic life sciences cluster in Europe with over 700 companies in the Basel Area, this iconic campus will become a meeting point for biotech and healthcare trailblazers. The landmark architecture by Herzog & de Meuron, developed by SENN, actively promotes exchange and offers an attractive and state-of-the-art working environment for startups, scaleups and established companies.

And we’re not alone

We collaborate with partners who share this vision. This event was the 9th iteration of the Technology Circle, an event series focused on industrial transformation, where we invite our partners to speak on their topic of expertise to a live audience.

Stay tuned for our next event, the 11th Technology Circle!

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